When one family member is afflicted with the disease of drug or alcohol addiction, the entire family is affected. People who abuse substances are likely to find themselves increasingly isolated from their families. Spouse or child abuse, divorce, accidents, and negligence, financial loss, stress and many other repercussions can take form. Family members and friends may experience feelings of guilt, concern, fear, abandonment, anger, anxiety and embarrassment. Long-term effects can include vital time away from your family. Children can be affected emotionally and intellectually by substance abuse in the family.